The California Highway Patrol reported that the crash occurred at Highway 20 and Harvey at about 6:15 p.m.
A Honda Civic and a motorcycle collided, leaving the roadway blocked, according to the CHP.
The CHP, Lake County Sheriff's Office and Northshore Fire responded to the scene. Tow companies also were called for the vehicles.
The motorcyclist and the passenger in the vehicle were both flown to Santa Rosa Memorial Hospital, the CHP reported.
Major injuries were reported, but the names of the crash victims and their specific injuries were not available late Saturday.
The roadway was reopened at approximately 7:36 p.m., the CHP reported.
CHP Officer Kory Reynolds is reportedly in charge of the investigation.
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